Impact of Solar Ultraviolet Radiation in the Expression of Type I Collagen in the Dermis

Ultraviolet radiation exposure is the dominant environmental determinant of all major forms skin cancer, and main cause prematurely aged that referred to as photoaging. Collagen type I (COL I) expressed differently along with dermis between healthy pathological tissues. The aim this study was understand impact solar in assess COL I. hematoxylin eosin staining protocol performed tissue paraffin blocks then they were stained immunohistochemically rabbit monoclonal anti-COL antibody. A total 270 slides studied an Olympus BX 41 microscope; we scored positively expression statistically analyzed IBM SPSS Statistics. Based on our results, observed elastosis changes structure skin’s collagen. In tissues, had a uniform dermis. tissues aging, weaker lost homogeneity. (non-melanoma cancers, NMSCs), precancerous lesions, benign lesions), be almost than aging body parts much below lesions. most severe extremities. degree severity relation age did not appear completely affected. Solar divides collagen more rapidly normal biological into photoaging, which replaces fibers skin. These results confirm previous studies, have shown decreases during photoaging even cancers. We conclude reduced result ultraviolet leading negative impacts